184179-08-6 | Ac-DEVD-CHO | 半胱胺酸蛋白酶-10
Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC?? = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC?? = 10 to 100 nM).
Ac-DEVD-CHO是聚(adp -核糖)聚合酶(PARP)被caspase-3裂解的有效抑制劑(IC??= 0.2 nM)。PARP的分裂發(fā)生在細胞凋亡的開始。肽醛能夠在體外減弱凋亡事件(IC??= 10至100 nM)。
編號:194344
中文名稱:半胱胺酸蛋白酶-10：Ac-Asp-Glu-Val-Asp-CHO
英文名:PASE-3 Inhibitor I; Ac-Asp-Glu-Val-Asp-CHO
CAS號:184179-08-6
單字母:Ac-DEVD-CHO
三字母:Ac-Asp-Glu-Val-Asp-CHO
氨基酸個數(shù):4
分子式:C20H30O11N4
平均分子量:502.47
精確分子量:502.19
等電點(PI):-
pH=7.0時的凈電荷數(shù):-3
平均親水性:1.875
疏水性值:-1.58
來源:化學(xué)合成
鹽體系:TFA鹽
儲存條件:-20攝氏度
標(biāo)簽:<span class="nolink">醛肽<span class="nolink">抑制劑相關(guān)肽
參考文獻：
10.1080/10428190701385181The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines
10.1016/j.jdermsci.2007.06.008Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage to HaCaT keratinocytes
10.1002/cbdv.200800354Antiproliferative and proapoptotic activities of a new class of pyrazole derivatives in HL-60 cells
