關(guān)鍵詞

白細(xì)胞介素 司庫(kù)奇尤單抗 免疫 單克隆抗體 幽門螺旋桿菌 白細(xì)胞介素-2 維奈托克 替雷利珠單抗

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#今日行業(yè)熱點(diǎn)#

①The Lancet Rheumatology：Safety and efficacy of secukinumab in patients with giant cell arteritis (TitAIN): a randomised, double-blind, placebo-controlled, phase 2 trial

臨床試驗(yàn)：靶向白細(xì)胞介素- 17A的單克隆抗體司庫(kù)奇尤單抗（Secukinumab）在巨細(xì)胞動(dòng)脈炎(TitAIN)患者的隨機(jī)、雙盲、安慰劑對(duì)照、Ⅱ期試驗(yàn)

DOI: 10.1016/S2665-9913(23)00101-7

②The Lancet Rheumatology：Mortality and immune-related adverse events after immune checkpoint inhibitor initiation for cancer among patients with pre-existing rheumatoid arthritis: a retrospective, comparative, cohort study

臨床研究：既往類風(fēng)濕關(guān)節(jié)炎患者接受免疫檢查點(diǎn)抑制劑用于癌癥后的死亡率和免疫相關(guān)不良事件

DOI:10.1016/S2665-9913(23)00064-4

③Nature Communications：A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders

阻斷性單克隆抗體揭示與遺傳性疾病相關(guān)的激活素受體樣激酶2 (ALK2)胞內(nèi)結(jié)構(gòu)域的二聚化

DOI: 10.1038/s41467-023-38746-5

④Cell Reports：Helicobacter spp. are prevalent in wild mice and protect from lethal Citrobacterrodentium infection in the absence of adaptive immunity

幽門螺桿菌在野生小鼠中富集，并在缺乏適應(yīng)性免疫的情況下保護(hù)小鼠免受致命性檸檬酸桿菌感染

DOI: 10.1016/j.celrep.2023.112549

⑤Journal of Neurology:A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing-remitting multiple sclerosis

臨床試驗(yàn)：低劑量白細(xì)胞介素-2 (interleukin-2, IL2LD)用于復(fù)發(fā)緩解型多發(fā)性硬化的隨機(jī)雙盲安慰劑對(duì)照試驗(yàn)

DOI: 10.1007/s00415-023-11690-6

⑥Expert Opinion on Pharmacotherapy：An update on the efficacy of Venetoclax for chronic lymphocytic leukemia

綜述：BCL2選擇性抑制劑維奈托克(Venetoclax)用于慢性淋巴細(xì)胞白血病(CLL)領(lǐng)域的最新進(jìn)展

DOI: 10.1080/14656566.2023.2218545

⑦替雷利珠單抗用于廣泛期小細(xì)胞肺癌患者的Ⅲ期臨床試驗(yàn)達(dá)到主要終點(diǎn)

⑧美國(guó)Neuralink腦機(jī)接口試驗(yàn)已獲得美國(guó)食品藥品監(jiān)督管理局（FDA）批準(zhǔn)，將啟動(dòng)首次人體臨床研究

⑨重組抗 IL-17 單克隆抗體SCT650C獲得澳大利亞Ia期新藥臨床試驗(yàn)許可，用于中重度斑塊狀銀屑病

⑩高選擇性血管內(nèi)皮生長(zhǎng)因子受體(“VEGFR”)-1、-2及-3抑制劑呋喹替尼(Fruquintinib)用于轉(zhuǎn)移性結(jié)直腸癌的新藥上市申請(qǐng)獲FDA受理并予以優(yōu)先審評(píng)

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