關(guān)鍵詞

逆轉(zhuǎn)錄 circRNA 抗原 堿基編輯器 免疫應(yīng)答?PARP7抑制劑 阿達(dá)木單抗 帕博利珠單抗 杰諾單抗

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#今日行業(yè)熱點(diǎn)#

①Cell：Antibody-Associated Reversal of ATTR Amyloidosis-Related Cardiomyopathy

R2機(jī)制下的DNA識別和RNA監(jiān)督的序列逆轉(zhuǎn)錄轉(zhuǎn)座機(jī)制

DOI: 10.1016/j.cell.2023.05.032

②Cancer Cell：Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia

白血病中環(huán)狀RNA(circRNA)驅(qū)動(dòng)MLL重組體內(nèi)的致癌染色體易位

DOI: 10.1016/j.ccell.2023.05.002

③Immunity：HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery

HLA-II免疫肽譜分析和深度學(xué)習(xí)揭示了抗原發(fā)現(xiàn)中的抗原性特征

DOI: 10.1016/j.immuni.2023.05.009

④Trends in Immunology：Base editors dissect genetic variants in human hematopoietic cells on a large scale

堿基編輯器大規(guī)模地剖析人類造血細(xì)胞和祖細(xì)胞 (HSPCs)的遺傳變異體

DOI: 10.1016/j.it.2023.05.009

⑤Trends in Immunology：Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data

綜述：多尺度幾何和拓?fù)浞治鲇糜趶膯渭?xì)胞數(shù)據(jù)確定和預(yù)測免疫應(yīng)答

DOI: 10.1016/j.it.2023.05.003

⑥Current Biology：A mechanism for differential control of axonal and dendritic spiking underlying learning in a cerebellum-like circuit

發(fā)現(xiàn)：在類似小腦的神經(jīng)回路中潛在學(xué)習(xí)的軸突和樹突的差異控制機(jī)制

DOI: 10.1016/j.cub.2023.05.040

⑦小分子新藥PARP7抑制劑JAB-26766獲國家藥監(jiān)局批準(zhǔn)用于晚期實(shí)體腫瘤的Ⅰ/Ⅱ期臨床研究

⑧原研藥阿達(dá)木單抗生物類似藥SCT630在國內(nèi)獲批上市，用于類風(fēng)濕關(guān)節(jié)炎、強(qiáng)直性脊柱炎、銀屑病、克羅恩病、葡萄膜炎、多關(guān)節(jié)型幼年特發(fā)性關(guān)節(jié)炎、兒童斑塊狀銀屑病和兒童克羅恩病等8個(gè)適應(yīng)癥

⑨FDA受理PD-1抑制劑帕博利珠單抗（Keytruda）的補(bǔ)充生物制品許可申請（sBLA ）用于晚期或不可切除膽道癌（BTC）

⑩PD-1產(chǎn)品杰諾單抗（GB226）用于復(fù)發(fā)╱難治性外周T細(xì)胞淋巴瘤（PTCL）的新藥上市申請未獲國家藥監(jiān)局批準(zhǔn)

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