質(zhì)量控制：95%+

純度級別：分析純AR

貯存方法：避光儲存

GalNAc-CPG允許合成siRNA-GalNAc綴合物。N-乙酰半乳糖胺（GalNAc）是一種定義明確的肝臟靶向部分，得益于其與去唾液酸糖蛋白受體（ASGPR）的高親和力。

GalNAc CPG allows the synthesis of siRNA - GalNAc laced. N-acetyl galactosamine (GalNAc) is a well-defined liver targeting part, due to its to sialic acid glycoprotein receptor (ASGPR) with high affinity.

通過將其直接與寡核苷酸結(jié)合或?qū)⑵湫揎椀教囟ǖ倪f送系統(tǒng)作為靶向部分，GalNAc在核酸療法的發(fā)展中取得了引人注目的成功。

Directly by the combined with few nuclear wast, acid or the targeted delivery system as part of the modification to the specific, GalNAc in the development of nucleic acid therapy has achieved remarkable success.

N-乙?；陌肴樘前罚℅alNAc）偶聯(lián)修飾是當(dāng)前最常用的小核酸藥物遞送系統(tǒng)。GalNAc是去唾液酸糖蛋白受體（ASGPR）配體，能以nM級高親和性結(jié)合ASGPR，隨后受體在網(wǎng)格蛋白介導(dǎo)的內(nèi)吞作用下將GalNAc及核酸攝取進(jìn)入細(xì)胞。GalNAc偶聯(lián)修飾的優(yōu)勢在于偶聯(lián)的核酸分子量較小，并且作用時(shí)效長達(dá)數(shù)月。但由于ASGPR僅在肝實(shí)質(zhì)細(xì)胞特異性高表達(dá)，存在組織局限性。

N - b of cool galactosamine (GalNAc) coupling modification is the most commonly used small nucleic acid drug delivery system. GalNAc is to sialic acid glycoprotein receptor (ASGPR) ligands, nM level high affinity to ASGPR, then under the action of receptor in clathrin mediated endocytosis GalNAc and nucleic acid uptake into the cells. GalNAc coupling modified advantage lies in the coupling of the nucleic acid molecular weight is small, and the effect of aging for months. But as a result of ASGPR only high specificity in the liver parenchyma cells, limitations exist organization.

以上關(guān)于GalNAc CPG? 的信息由 西安凱新?生物科技有限公司Z提供，詳情可咨詢